Maculopathy a a Complication of Blood–Brain Barrier Diruption in Patient with Central Nervou ytem Lymphoma Original Reearch Article

Purpoe To report on the development of viually ignificant maculopathy aociated with blood–brain barrier diruption (BBBD) therapy for the treatment of central nervou ytem (CN) lymphoma. Deign Retropective cae erie. Method Chart review of 20 patient undergoing BBBD therapy for treatment of CN lymphoma at the Cleveland Clinic. Patient with documented maculopathy were included in analyi. Reult even (54%) of 13 patient were identified with new macular retinal pigment epithelium (RPE) change after BBBD treatment. The RPE change conited of fine clump of hyperpigmentation in the foveal region aociated with variable degree of RPE lo. Thee change were bilateral but often aymmetric. Two patient had decreaed viual acuity reulting from maculopathy. One patient had documented progreion of maculopathy after completion of treatment. Concluion Maculopathy i a frequent finding after BBBD therapy for CN lymphoma.