Haptoglobin polymorphism, a genetic risk factor in coronary artery bypass surgery

Haptoglobin (Hp) 2-2 type has been associated with accumulation of atherosclerotic lesions in essential hypertension. The aim of this study was to investigate the relationship between Hp type and the extension of coronary lesions in 765 male patients who underwent coronary artery bypass grafting (CABG). In this group, relative Hp1 (0.418) and Hp2 (0.582) allele frequencies were comparable with those of the reference population. Candidate CABG patients with a Hp 2-2 type were overrepresented in the younger (<45 years) age group (P<0.05). Hp 2-2 patients needed more bypass grafts than Hp 1-1 patients (relative risk 1.92, 95% C.I. 1.24–2.96). The Hp 2-2 type was overrepresented among victims of a previous acute myocardial infarction (P<0.05), and among patients with a lower (<45 years) age at infarction (P<0.05). In patients who already underwent a previous CABG, graft survival time was shortest in Hp 2-2 type (P<0.05). Patients with a Hp 2-2 type more likely develop atherosclerotic lesions despite comparable serum lipid concentrations.