Title of article
Interaction of caveolin with 7-ketocholesterol
Author/Authors
Leanne S. Sleer، نويسنده , , Andrew J. Brown، نويسنده , , Keith K. Stanley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
7
From page
49
To page
55
Abstract
Caveolin is an integral membrane protein that interacts with cholesterol in glycosphingolipid-rich rafts at the cell surface. We have examined the interaction of recombinant His-tagged caveolin-1 with cholesterol and 7-keto cholesterol, the most abundant non-enzymatically formed oxysterol found in oxidised LDL and atheromatous plaque. Our data show that caveolin-1 is able to interact with both sterols. This might have consequences for sterol transport and the signalling properties of cells during atherosclerosis.
Keywords
DOPC , dioleoyl phosphatidyl choline , IPTG , isopropyl-?-D-thiogalactopyranoside , 7KC , 7 ketocholesterol , LDL , low density lipoprotein
Journal title
Atherosclerosis
Serial Year
2001
Journal title
Atherosclerosis
Record number
630536
Link To Document