Nucleated red blood cells in concordant, appropriate-for-gestational age twins

Objectives The purpose of this study was to test the hypothesis that neonatal nucleated red blood cell (RBC) counts are elevated in nondiscordant twins compared with singletons. Study design We compared absolute nucleated RBC counts taken after birth in 2 groups of term, appropriate-for-gestational age infants; 74 concordant twins, and 29 singleton control infants. We excluded infants with factors associated with a potential increase in absolute nucleated RBC counts. Results Birth weight and gestational age were significantly lower in twins than in singletons (P< .01). Hematocrit, absolute nucleated RBC count, and corrected lymphocyte counts were significantly higher in twins (P< .01). In multiple regression, the significantly higher absolute nucleated RBC count in twins remained significantly higher even after taking into account gestational age and Apgar scores. Conclusion Concordant, appropriate-for-gestational age twins have increased nucleated RBCs at birth compared with singleton control infants.