Impaired stress-induced pressure natriuresis increases cardiovascularload in African American youths

Abstract Background We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load. Methods The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period. Results: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P< .03) increase in BP (P< .001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P< .05), resulted from a volume-mediated (r = 0.55; P< .002) increase in BP (P< .001). Conclusions: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans.