Studies on the Synthesis of Novel 2,4-Thiazolidinedione Derivatives with Antidiabetic Activity

A new series of thiazolidinedione derivatives were synthesized. The structures of these compounds were established by means of IR, 1H-NMR and elemental analysis. All of the compounds were screened for antidiabetic activity on albino rats. Most of the compounds showed significant antidiabetic activity when compared with the standard drug glibenclamide.