Effect of a Xenogeneic Urinary Bladder Injectable Bioscaffold on Lameness in Dogs with Osteoarthritis of the Coxofemoral Joint (Hip): A randomized, Double Blinded Controlled Trial

More than 20% of all dogs in the United States suffer from lameness and pain associ¬ated with chronic osteoarthritis (OA). Many times the current therapeutic modalities are not well tolerated by the pet leaving, few choices for alleviating suffering. Regenera¬tive medicine brings new modalities that may aid dogs that either do not respond to or cannot tolerate traditional therapy. The pres¬ent study evaluated the efficacy of porcine urinary bladder extracellular matrix (UBM- ECM), an acellular bio-inductive scaffold, to treat dogs with osteoarthritis of the hip joint. This study demonstrates that a single intra-articular injection of UBM-ECM sig¬nificantly improved activity, lameness, and range of motion scores compared to control dogs. This is the first randomized controlled clinical trial reporting the effectiveness of a bioinductive scaffold in dogs with OA.