The Efficacy of Pyriprole Topical Solution Against Infestations of Adult Ticks (Ixodes scapularis, Amblyomma americanum and Dermacentor variabilis on Dogs

In three separate studies, the efficacy of a single treatment with a 12.5% pyriprole spot-on solution (Prac-tic®) was investi¬gated against induced infestation with I. scapularis, A. americanum, or D. variabilis on dogs. For each tick species, one group of eight dogs treated with a placebo solution was compared with another group treated once with the 12.5% pyriprole spot-on solu¬tion at a dose rate of at least 12.5 mg/kg. The dogs were infested with 50 unfed adult ticks of the respective species at various time points during the 4 weeks that followed treatment and the surviving ticks were re¬corded 48 and 72 hours after re-infestation.