First Report on Pelger-Huet Anomaly in a Male Basenji Dog in Libya

Pelger-Huet (P-H) anomaly is a benign congenital anomaly of leukocytes, characterized by nuclear hyposegmentation of granulocytes. Patients with heterozygous form of P-H anomaly are not immunodeficient and not predisposed to infection. In this study, P-H anomaly has been detected during a routine blood examination conducted on a clinically normal five years old male Basenji dog. Nuclear hyposegmentation of neutrophils with mature coarse chromatin pattern was noticed. As the animal was in a good health and all other blood parameters were within normal reference range, P-H anomaly was suspected. Acquired, pseudo P-H anomaly was excluded by detecting the same unique nuclear pattern in three successive blood samples collected at month intervals. Nuclear morphology was variable as dumbbell shaped, peanut shaped, band, round or bilobed forms were mostly detected in the neutrophils. It is the first report for this anomaly in Libya.