Evaluation of Immunomodulation Potential of Red Velvet Mite, T .grandissimum Using Swiss Albino Mice

The present study was carried out to findout immunomodulatory potential of red velvet mites, T. grandissimum against chosen antigen (SRBC) using animal model, swiss albino mice. Immunological parameters such as antibody titre, delayed type hypersensitivity, lymphocyte sub population are used to evaluate immunomodulatory potential of test sample. Oral administration of the methanol extracts of T. grandissimum (100mg/kg body weight, 150mg/kg body weight) for 7 days around immunization, caused a dose-related decrease in DTH (40% and 50% respectively) reactivity in mice. This indicated the effectiveness of red velvet mite extracts to inhibit DTH reactiveness. The augmentation of the humoral response as evidenced by an enhancement of antibody responsiveness to SRBC in mice as a consequence of RVME administration indicates the enhanced responsiveness of lymphocytes subsets involved in antibody synthesis. The results proved that the extracts of the mites enhanced humoral immune response. The antibody titre value of control mice showed 5.6±0.4 log2 titre, but mite extracts 100 mg/kg/bw and 150 mg/kg/bw administered mice showed 7.8±0.6 and 8.8±0.5 log2 titre values respectively. From the present investigation confirmed the immunomodulatory potential of red velvet mites