Title of article
Synthesis and cellular uptake of cell delivering PNA–peptide conjugates
Author/Authors
Diaz-Mochon، Juan J. نويسنده , , Bialy، Laurent نويسنده , , Watson، Jon نويسنده , , S?nchez-Martin، Rosario M. نويسنده , , Bradley، Mark نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
-3315
From page
3316
To page
0
Abstract
The synthesis and cellular uptake of fluorescently labelled PNA–peptide conjugates is described; Dde/Mmt protected PNA monomers, fully orthogonal to Fmoc chemistry, were used to develop a flexible strategy to give Peptide Nucleic Acids conjugated to tri- and hepta-arginine and the short basic Tat48–57 peptide as examples of cellular penetrating peptides, thereby allowing efficient cellular delivery of PNA into cells.
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Serial Year
2005
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Record number
68251
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