Nanocrystalline copper(II) oxide-catalyzed one-pot four-component synthesis of polyhydroquinoline derivativesunder solvent-free conditions

The efficient and environmentally friendly method for the one-pot synthesis of polyhydroquinolines has been developed in the presence of CuO nanoparticles. The multi-component reactions of aldehydes, dimedone, ethyl acetoacetate andammonium acetate were carried out under solvent-free conditions to a fford some polyhydroquinoline derivatives. This method provides several advantages including high yields, low reaction times and little catalyst loading.