Title of article
A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer
Author/Authors
Gloster، Tracey نويسنده , , Williams، Spencer J. نويسنده , , Tarling، Chris A. نويسنده , , Roberts، Shirley نويسنده , , Dupont، Claude نويسنده , , Jodoin، Pascale نويسنده , , Shareck، François نويسنده , , Withers، Stephen G. نويسنده , , Davies، Gideon J. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
-943
From page
944
To page
0
Abstract
The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid–base.
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Serial Year
2003
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Record number
68483
Link To Document