A Clidinium Potentiometric Membrane Sensor for Determination of Clidinium in Pharmaceutical Formulation

This work introduces a PVC membrane sensor for determination of clidinium active ingredient. For the membrane preparation, clidinium-tetraphenyl borate ion-pair was employed as a sensing material in the PVC membrane. Several plasticizers were studied in the membrane composition dibutyl phthalate (DBP), benzylacetat (BA), and nitrobenzene (NB). After a series of experiments, the best electrode response was obtained from a membrane composed of NB. The electrodes illustrated a fast, stable and Nernstian response over a wide clidinium bromide concentration range of 1×10-5 to 1×10-1 M, in the pH range of 4.0–10.0.