The Neurotoxic Effects of Lindane at Acute and Subchronic Dosages

Lindane (γ-HCH), a multipurpose organochlorine pesticide, was administered to Rattus norvegicus at acute and subchronic dosages. The dosage given was half that corresponding to LD50 (half the lethal dose). For rats, this is 60 mg/kg of body weight. The acute dose was administered on a single occasion, while the subchronic dosage was administered on 10 occasions over a 30-day period. Six types of behavior pattern based on the neurotoxic register were established for the acute dosage. Significant decreases in the levels of the neurotransmitter dopamine were also found, in similar proportions for both types of dose. The difference between single dose intoxication and poisoning by overlapping doses must be underlined, as the second type may produce the same effects without giving rise to clear symptoms.