Analysis of difference in vivo effects of TCDD between c-src +/+ mice, c-src deficient, −/+ and −/− B6, 129-Srctm l sor mice and their wild-type littermates

Toxicities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were tested on two strains of c-src deficient B6, 129-Srctm l sor mice, c-src −/+ and c-src −/− and their matched wild-type littermates c-src +/+ mice along with another c-src +/+ mice, from the same genetic lineage, B6, 129-Fos tm l Pa mice. The most conspicuous effect of c-src deficiency on the toxicity of TCDD appears to be the reduced hepatotoxicity. TCDD-treated c-src deficient mice show only modest degrees of hepatomegaly and triglycerides accumulation as compared to treated wild-type mice.