A Train of Thoughts on Gene Mapping

Complex traits, by definition, are the pheonotypic outcome from multiple interacting genes. The traditional analysis of association studies on complex traits is to test one locus at a time, but a better approach is to analyze all markers simultaneously. We previously proposed a two-stage approach, first selecting the influential markers and then modeling main and interaction effects of these markers. Here we introduce alternative approaches to marker selection and discuss issues regarding analytical tools for disease gene mapping, marker selection, and statistical modeling.