Title of article
Antifilarial activity of some 2H-1-benzopyran-2-ones (coumarins)
Author/Authors
R.P Tripathi، نويسنده , , R Tripathi، نويسنده , , A.P Bhaduri، نويسنده , , S.N Singh، نويسنده , , R.K Chatterjee، نويسنده , , P.K Murthy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
6
From page
101
To page
106
Abstract
Six synthetic 2H-1-benzopyran-2-one (cournarin) derivatives (CDRI compounds # 1, 2, 3, 4, 5 and 6) were evaluated for filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae infections in cotton rats (Sigmodon hispidus) and Mastomys coucha respectively. Significant effects on macrofilariae (>80% death/sterilisation) were detected with compounds #2, 3 and 6 against L. carinii and/or A. viteae. Thus detection of filaricidal activity in benzopyrones, which are so far known for anti-inflammatory activity, provides a new lead for development of better filaricidal agents for combating filariasis.
Keywords
2H-1-benzopyran-2-ones , coumarin , Antifilarial , Litomosoides carinii , Acanthocheilonema viteae
Journal title
Acta Tropica
Serial Year
2000
Journal title
Acta Tropica
Record number
777578
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