Title of article
The synthesis of 5-substituted camptothecins as potential inhibitors of DNA topoisomerase I
Author/Authors
Hui-Kang Wang، نويسنده , , Su-Yin Lin، نويسنده , , Kou-Maou Hwang، نويسنده , , Andrew T. McPhail، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
77
To page
82
Abstract
Four new 5-substituted camptothecins (4–7) have been synthesized and evaluated for DNA topoisomerase I inhibition. The results suggested that the pyridone moiety in the D ring of camptothecin plays a crucial role in determining its activity and that the 5 position of the C ring should be unsubstituted for retention of activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787284
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