Title of article
Chakrapani Subramanyam, Malcolm R. Bell, Edward Ferguson, Robert G. Gordon, Richard P. Dunlap, Catherine Franke, Albert J. Mura
Author/Authors
Chakrapani Subramanyam، نويسنده , , Malcolm R. Bell، نويسنده , , Arup K. Ghose، نويسنده , , Virendra Kumar Mishra، نويسنده , , Richard P. Dunlap، نويسنده , , Catherine Franke، نويسنده , , Albert J. Mura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
325
To page
330
Abstract
Potent mechanism based inhibition of human leukocyte elastase (HLE) by tetrahydrobenzisothiazolones (2) is described. Structure activity relationships studies led to the identification of WIN 62816 (2c), the most potent inhibitor in this series with a Ki* = 0.7 nM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787330
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