Title of article
Potent mammalian topoisomerase II inhibitors: 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-substituted-quinolines
Author/Authors
Gee-Hong Kuo، نويسنده , , Michael A. Eissenstat، نويسنده , , Mark P. Wentland، نويسنده , , Ron G. Robinson، نويسنده , , Kristina M. Klingbeil، نويسنده , , Debbie W. Danz، نويسنده , , Susan A. Coughlin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
399
To page
404
Abstract
A series of novel 4-substituted-1,4-dihydro-quinolines 3 were prepared and found to exhibit moderate to excellent mammalian topo II inhibitory activity. Among the compounds prepared, in general, the nitrogen analogues are the most active compounds and the sulfur analogue is the least active one.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787344
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