Title of article
Aminodiol HIV protease inhibitors. 2. 1,1-Dimethyl-2-hydroxyethyl carbamate derivatives with enhanced potency
Author/Authors
G. S. Bisacchi، نويسنده , , S. Ahmad، نويسنده , , M. Alam، نويسنده , , A. Ashfaq، نويسنده , , J. Barrish، نويسنده , , P. T. W. Cheng، نويسنده , , J. Greytok، نويسنده , , M. Hermsmeier، نويسنده , , P. -F. Lin، نويسنده , , Z. Merchant، نويسنده , , M. Skoog، نويسنده , , S. Spergel، نويسنده , , R. Zahler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
459
To page
464
Abstract
A series of BOC-modified analogs of the aminodiol HIV protease inhibitor BMS-182193 (1) was prepared and tested for inhibitory activity against the enzyme and the virus in cell culture. The hydroxymodified analogs, 5 and 20, showed enhanced potency against the protease and 5 was more active than 1 against the virus in cell culture.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787354
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