Title of article
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs
Author/Authors
Roshantha A. S. Chandraratna، نويسنده , , Samuel J. Gillett، نويسنده , , Tae K. Song، نويسنده , , John Attard، نويسنده , , Sagar Vuligonda، نويسنده , , Michael E. Garst، نويسنده , , Taghreed Arefieg، نويسنده , , Daniel W. Gil، نويسنده , , Larry Wheeler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
5
From page
523
To page
527
Abstract
The biological activity of retinoids are determined by their ability to activate one or more of six nuclear retinoid receptors (RARs and RXRs). We describe rigid, acetylenic retinoids that selectively transactivate through the RARß and RAR/Gg subtypes and demonstrate their potent anti-proliferative activity in the skin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787366
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