Title of article
The enantiomer of strychnine is a weak antagonist of the inhibitory glycine receptor
Author/Authors
Steven D. Knight، نويسنده , , Ricardo Miledi، نويسنده , , Quoc-Thang Nguyen، نويسنده , , Larry E. Overman، نويسنده , , Garry Pairaudeau، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
749
To page
752
Abstract
ent-Strychnine (2) was synthesized for the first time from (1R,4S)-(+)-4-hydroxy-2-cyclopentenyl acetate (3) by a slight modification of the sequence recently employed to prepare natural (−)-strychnine. ent-Strychnine is about a 1000 fold weaker antagonist of the inhibitory glycine receptor expressed in oocytes than natural (−)-strychnine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787410
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