Title of article
Structure-activity and biophysical studies of the C-terminal hexapeptide of endothelin
Author/Authors
Daniele M. Leonard، نويسنده , , Michael D. Reily، نويسنده , , James B. Dunbar Jr.، نويسنده , , Katherine E. Holub، نويسنده , , Wayne L. Cody، نويسنده , , Kristen E. Hill، نويسنده , , Kathleen M. Welch، نويسنده , , Michael A. Flynn، نويسنده , , Elwood E. Reynolds، نويسنده , , Annette M. Doherty، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
967
To page
972
Abstract
A series of endothelin-1 [16–21] analogs, designed to incorporate random coil and β-turn conformations, was synthesized. Compounds were compared for their endothelin receptor binding affinity and functional activity relative to the native sequence. They were studied by NMR spectroscopy in an attempt to elucidate the bioactive conformation of the C-terminal region.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787452
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