Title of article
Reduced amide bond neurotensin 8–13 mimetics with potent in vivo activity
Author/Authors
D. J. Wustrow، نويسنده , , M. D. Davis، نويسنده , , H. C. Akunne، نويسنده , , A. E. Corbin، نويسنده , , J. N. Wiley، نويسنده , , L. D. Wise، نويسنده , , T. G. Heffner، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
997
To page
1002
Abstract
Appropriately substituted 8–9 (ΨCH2NH) isosteres of neurotensin (NT) 8–13 have been found which are active as NT agonists in vitro and in vivo. SAR studies suggest that preventing amide bond hydrolysis at the 8–9 and 11–12 positions of NT(8–13) mimetics is important for producing compounds with potent activity in vivo. Other simplified replacements for the Arg-Arg portion of NT(8–13) are reported.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787457
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