Title of article
Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors. I
Author/Authors
Nobuyuki Hamanaka، نويسنده , , Kanji Takahashi، نويسنده , , Yuuki Nagao، نويسنده , , Kazuhiko Torisu، نويسنده , , Satoshi Shigeoka، نويسنده , , Sumikazu Hamada، نويسنده , , Hitoshi Kato، نويسنده , , Hidekado Tokumoto، نويسنده , , Kigen Kondo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1087
To page
1090
Abstract
By incorporation of a pyridine moiety into compounds shown to be PGI2 agonists, we have synthesized a series of compounds which also show potent thromboxane synthase inhibitory activity. Agents 9 and 14 with the 3-substituted pyridine moiety show a combined properties of PGI2 agonist and TXA2 synthase inhibitor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787474
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