Title of article
Potent dual antagonists of endothelin and angiotensin II receptors derived from α-phenoxyphenylacetic acids (Part III)
Author/Authors
Thomas F. Walsh، نويسنده , , Kenneth J. Fitch، نويسنده , , David L. Williams Jr.، نويسنده , , Kathryn L. Murphy، نويسنده , , Nancy A. Nolan، نويسنده , , Douglas J. Pettibone، نويسنده , , Raymond S. L. Chang، نويسنده , , Stacey S. OʹMalley، نويسنده , , Bradley V. Clineschmidt، نويسنده , , Daniel F. Veber، نويسنده , , William J. Greenlee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1155
To page
1158
Abstract
Screening a collection of α-phenoxyphenylacetic acid derived angiotensin II antagonists identified weak actives in an endothelin receptor binding assay. Synthetic modification of one of these leads has provided L-746,072 (13), a highly potent dual antagonist of angiotensin II and endothelin receptors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787487
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