Title of article
Synthesis and antiviral activity of rigid acyclonucleotide analogs
Author/Authors
Patrick J. Casara، نويسنده , , Jean-Michel Altenburger، نويسنده , , Debra L. Taylor، نويسنده , , A. Stanley Tyms، نويسنده , , Michael Kenny، نويسنده , , Jean-François Navé، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1275
To page
1280
Abstract
The synthesis, anti-HIV-1 and anti-herpesvirus activities of new rigid acyclonucleotide analogs are described. 9-[2-methylidene-3-(phosphonomethoxy)propyl]guanine 1a exhibits in vitro anti-HIV-1 activity similar to that of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Compound 1a is 9-fold less toxic to human T-lymphoid cells MT-4 than PMEA.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787510
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