Title of article
The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.
Author/Authors
A. Marfat، نويسنده , , R. Chambers، نويسنده , , J. Cheng، نويسنده , , K. Cooper، نويسنده , , D. Damon، نويسنده , , J. Delehunt، نويسنده , , J. Eggler، نويسنده , , H. Masamune، نويسنده , , Cathy L. Melvin، نويسنده , , J. Watson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1377
To page
1382
Abstract
The combination of key structural pharmacophores found in known leukotriene D4 (LTD4) receptor antagonists with those of potent platelet activating factor (PAF) receptor antagonist UK-74,505 has led to the synthesis of hybrid compounds CP-96,021 and CP-96,486. These compounds represent the first known balanced, combined and orally active LTD4/PAF receptor antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787527
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