Title of article
Design and syntheses of 4-acylaminopyridine derivatives: Novel high affinity choline uptake enhancers II
Author/Authors
Haruyuki Chaki، نويسنده , , Haruko Yamabe، نويسنده , , Mamoru Sugano، نويسنده , , Shuji Morita، نويسنده , , Tomoko Bessho، نويسنده , , Reiko Tabata، نويسنده , , Ken-ichi Saito، نويسنده , , Mitsuo Egawa، نويسنده , , Akihiro Tobe، نويسنده , , Yasuhiro Morinaka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1495
To page
1500
Abstract
The synthesis of 4-acylaminopyridine derivatives and their high affinity choline uptake improvement activities are described. N-propylcarbonyltetrahydroaminoacridine (1) was selected as a lead compound. Modification of its ring structure and acyl moiety led some active compounds. Among them, 9d (MKC-231) showed the highest activity. This compound is expected to be a unique medicine for Alzheimerʹs disease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787548
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