Title of article
Synthesis and biological activity of enantiomers of a conformationally restricted muscarone analog
Author/Authors
Edwin S. C. Wu، نويسنده , , Robert A. Mack، نويسنده , , Alex Kover، نويسنده , , James T. Loch III، نويسنده , , George Mullen، نويسنده , , Robert J. Murray، نويسنده , , John C. Gordon، نويسنده , , Anthony C. Machulskis، نويسنده , , Sally A. McCreedy، نويسنده , , James C. Blosser، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1813
To page
1818
Abstract
A short and efficient synthesis of both enantiomers of 2,8-dimethyl-1-oxa-8-azaspiro[4.5]-decan-3-one is described. The biological activity of the racemate resides predominantly in the S-enantiomer. While the S-isomer is a full M2-agonist, the R-isomer is devoid of M2 efficacy.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787605
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