Title of article
Rational design of irreversible, pseudo-C2-symmetric hiv-1 protease inhibitors
Author/Authors
Chihyo Park، نويسنده , , Jong Sung Koh، نويسنده , , Young Chan Son، نويسنده , , Ho-il Choi، نويسنده , , Chang Sun Lee، نويسنده , , Nakyen Choy، نويسنده , , Kwang Yul Moon، نويسنده , , Won Hee Jung، نويسنده , , Sung-Chun Kim، نويسنده , , Heungsik Yoon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1843
To page
1848
Abstract
Pseudo-C2-symmetric irreversible inhibitors of HIV-1 protease containing cis-epoxide were designed, synthesized, and kinetically characterized. Introduction of a Gly residue into P1ʹ of the inactivators yielded strong time-dependent irreversible ones with kina/Ki ranging from 1.5×108 to 3.4×105 M−1min−1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787611
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