Title of article
2-Substituted 2-aminoethanol: Minimum essential structure for immunosuppressive activity of ISP-I (Myriocin)
Author/Authors
Tetsuro Fujita، نويسنده , , Ryoji Hirose، نويسنده , , Norimitsu Hamamichi، نويسنده , , Yuuki Kitao، نويسنده , , Shigeo Sasaki، نويسنده , , Masahiko Yoneta، نويسنده , , Kenji Chiba، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1857
To page
1860
Abstract
2-Substituted 2-aminoethanol was shown to be the minimum essential structure for the immunosuppressive activity of ISP-i (myriocin, thermozymocidin) by simplification of 2-substituted 2-amino-1,3-propanediol, which was generated by modification of ISP-I. Among the series, 2-amino-4-(4-octylphenyl)butanol hydrochloride displayed comparably potent activity to 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride, FTY720.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787614
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