Title of article
Novel open-ring analogues of N5,N10-methylenetetrahydrofolic acid with selective activity against brain tumor
Author/Authors
Hui-po Wang، نويسنده , , Tung-shing Bai، نويسنده , , On Lee، نويسنده , , Kai-der Ker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1909
To page
1912
Abstract
A series of 5-(4-substituted-1-piperazinyl)pyrimidines were synthesized as open-ring analogues of N5,N10-methylene-tetrahydrofolic acid. Compounds 6, 7, 8, 9 and 11 showed selective cytotoxicity on SNB75 human CNS cancer cell line with growth inhibition (GI50) ranged from 1.39 × 10−7 M to less than 10−8 M.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787622
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