Title of article
Synthesis and β-lactamase inhibitory evaluation of novel 6α-halo-2β-chloromethyl-2α-methylpenam-3α-carboxylic acids and their sulfones and 6α-halo-2β-mercaptobenzothiazolylmethyl-2α-methylpenam-3α-carboxylic acids
Author/Authors
Gerardo O. Danelon، نويسنده , , Ernesto G. Mata، نويسنده , , Oreste A. Mascaretti، نويسنده , , Javier Girardini، نويسنده , , Martin Marro and، نويسنده , , Oscar A. Roveri، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
2037
To page
2040
Abstract
The synthesis and the inhibitory activity against β-lactamase I from Bacillus cereus is described for a new series of 6α-bromo, chloro or fluoro-2β-chloromethyl-2α-methylpenam-3α-carboxylic acids (5a-c) and their corresponding sulfones 6a-c and 6α-bromo, chloro or fluoro-2β-mercaptobenzothiazolylmethyl-2α-methylpenam-3α-carboxylic acids (8a-c). Among the novel compounds, the highest activity was expressed by 6α-chloro-2β-chloromethyl-2α-methylpenam-3α-carboxylic acid 1,1-dioxide (6b).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787649
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