Title of article
Synthesis and pharmacological activities of a novel tripeptide mimetic dopamine prodrug
Author/Authors
Hui-po Wang، نويسنده , , Jia-Shuai Lee، نويسنده , , Ming Cheng Tsai، نويسنده , , Hsiao-Hwa Lu، نويسنده , , Wenlie Hsu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
2195
To page
2198
Abstract
-p-hydroxyphenylglycine- -proline was attached to -dopa as delivery tool for improving the oral absorption. This tripeptide prodrug 1 of dopamine was well absorbed in a perfusion study in rat intestine, devoid of dopamine-like side effects on isolated smooth muscles and significantly inhibited the (+)-methamphetamine-induced rotation in nigrostriatal-lesioned rats, suggesting of anti-Parkinsonism effect.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787679
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