Title of article
Inhibitors of acyl-coa:cholesterol acyltransferase (ACAT). 15. sulfonylurea inhibitors with excellent hypocholesterolemic activity in vivo.
Author/Authors
Bruce D. Roth، نويسنده , , W. Howard Roark، نويسنده , , Joseph A. Picard، نويسنده , , Richard L. Stanfield، نويسنده , , Richard F. Bousley، نويسنده , , Maureen K. Anderson، نويسنده , , Katherine L. Hamelehle، نويسنده , , Reynold Homan، نويسنده , , Brian R. Krause، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
2367
To page
2370
Abstract
A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma cholesterol in cholesterol-fed rats in vivo. Although compounds from this series were generally weak inhibitors of ACAT in vitro, several displayed excellent hypocholesterolemic activity in vivo.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787711
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