Title of article
Inhibition of matrix metalloproteinases by N-carboxyalkyl dipeptides: Enhanced potency and selectivity with substituted P1′ homophenylalanines
Author/Authors
Soumya P. Sahoo، نويسنده , , Charles G. Caldwell، نويسنده , , Kevin T. Chapman، نويسنده , , Philippe L. Durette، نويسنده , , Craig K. Esser، نويسنده , , Ihor E. Kopka، نويسنده , , Scott A. Polo، نويسنده , , Kelly M. Sperow، نويسنده , , Lisa M. Niedzwiecki، نويسنده , , Maria Izquierdo-Martin، نويسنده , , Benedict C. Chang، نويسنده , , Richard K. Harrison، نويسنده , , Ross L. Stein، نويسنده , , Malcolm MacCoss، نويسنده , , William K. Hagmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2441
To page
2446
Abstract
A series of N-carboxyalkyl dipeptides were synthesized to evaluate their inhibitory activities against human stromelysin-1(MMP-3), collagenase(MMP-1), and gelatinase-A(MMP-2). Structures with a homophenylalanine residue at P1′ substituted at the para position with small alkyl groups are potent inhibitors of (MMP-3) and (MMP-2) (Ki′ s 2–40 nM), but weak inhibitors of (MMP-1).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787725
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