Title of article
Increase of the anti-HIV activity of D4T in human T-cell culture by the use of the sate pronucleotide approach
Author/Authors
Jean-Luc Girardet، نويسنده , , Christian Perigaud، نويسنده , , Anne-Marie Aubertin، نويسنده , , Gilles Gosselin، نويسنده , , Andre Kirn، نويسنده , , Jean-Louis Imbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
2981
To page
2984
Abstract
The bis(S-acetyl-2-thioethyl) phosphotriester derivative of 2′,3′-didehydro-2′,3′-dideoxythymidine has been synthesized and evaluated for its inhibitory effects on the replication of HIV-1 in several cell culture systems. This pronucleotide showed potent anti-HIV activity and proved to be significantly superior to the parent nucleoside with regard to the antiviral efficiency.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787820
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