Title of article
6N-Cinnamoyl-β-naltrexamine and its p-nitro derivative. High efficacy κ-opioid agonists with weak antagonist actions
Author/Authors
Ian Derrick، نويسنده , , Humphrey A. Moynihan، نويسنده , , Jillian Broadbear، نويسنده , , James H. Woods، نويسنده , , John W. Lewis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
167
To page
172
Abstract
6N-cinnamoyl-β-naltrexamine and its p-nitro derivative (7 and 8) are κ-opioid agonists of high potency and exceptional efficacy and are only weakly effective μ opioid antagonists. This contrasts with the p-methyl analogue which has only low efficacy κ-agonism but is a selective irreversible μ-antagonist like β-FNA.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787879
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