Title of article
Quinoline-substituted dihydroindoles as cysLT1 (LTD4 receptor) antagonists
Author/Authors
J. Scott Sawyer، نويسنده , , K. Jeff Thrasher، نويسنده , , Nicholas J. Bach، نويسنده , , Peter W. Stengel، نويسنده , , Sandra L. Cockerham، نويسنده , , Steven A. Silbaugh، نويسنده , , Carlos R. Roman، نويسنده , , Larry L. Froelich، نويسنده , , Jerome H. Fleisch، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
249
To page
252
Abstract
A series of quinoline-substituted dihydroindoles has been synthesized and evaluated as antagonists of the cysLT1 receptor. This series, exemplified by 2 (LY302905; pKi = 8.3 for inhibition of binding of 3H-LTD4 to guinea pig lung membranes), represents reduced analogues of the corresponding indoles that were previously shown to be potent, orally active cysLT1 receptor antagonists. These dihydroindole compounds generally displayed increased in vitro and in vivo (oral) activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787894
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