Title of article
Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators
Author/Authors
Bruce E. Maryanoff، نويسنده , , David F. McComsey، نويسنده , , Winston Ho، نويسنده , , Richard P. Shank، نويسنده , , Barry Dubinsky، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
333
To page
338
Abstract
We have further explored the structure-activity relationships of pyrido[1,2-a]benzimidazole (PBI) derivatives (viz. prototype 1), a novel series of central GABA-A receptor modulators, with the intent of enhancing oral efficacy. A study involving the introduction of acidic or basic groups led to the identification of RWJ-38293 (3a) as a potential anxiolytic agent.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787912
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