Title of article
Synthesis of new 3,4-disubstituted pyrrolidines as thromboxane A2/prostaglandin H2 (TP) receptor antagonists
Author/Authors
Thierry Dubuffet، نويسنده , , Olivier Muller، نويسنده , , Serge S. Simonet، نويسنده , , Jean-Jacques Descombes، نويسنده , , Michel Laubie، نويسنده , , Tony J. Verbeuren، نويسنده , , Gilbert Lavielle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
349
To page
352
Abstract
The synthesis and TP-receptor antagonistic activity of a series of 3,4-disubstituted pyrrolidines is described. The sulfonamide was the most potent TP-receptor antagonist in this series with a pA2 value of 9.5 in isolated guinea pig trachea.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787915
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