Title of article
Synthesis and antibacterial activity of 4- and 8-methoxy trinems
Author/Authors
Daniele Andreotti، نويسنده , , Tino Rossi، نويسنده , , Giovanni Gaviraghi، نويسنده , , Daniele Donati، نويسنده , , Carla Marchioro، نويسنده , , Enza Di Modugno، نويسنده , , Alcide Perboni، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
491
To page
496
Abstract
The synthesis of all the isomers of 8-methoxy-(9S,10S,12R)-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo-[7.2.0.03,8]-undec-2-ene-carboxylates2 and 4-methoxy-(9R,10S,12R)-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo-[7.2.0.03,8]-undec-2-ene-carboxylates3is described. The biological data obtained indicated that the (4S,8S)-4-methoxy derivative ( 3b ) is the best compound in terms of microbiological activity, breadth of spectrum of action and stability to hydrolytic enzymes, namely β-lactamases.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787944
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