Title of article
Glycomimetic selectin inhibitors: (α-D-mannopyranosyloxy)methylbiphenyls
Author/Authors
Brian Dupré، نويسنده , , Huong Bui، نويسنده , , Ian L. Scott، نويسنده , , Robert V. Market، نويسنده , , Karin M. Keller، نويسنده , , Pamela J. Beck، نويسنده , , Timothy P. Kogan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
569
To page
572
Abstract
A novel class of biphenyl-based compounds were investigated for their ability to inhibit sialyl Lewis X (sLex) dependent binding of HL-60 cells to E- and P-selectin fusion proteins. Compounds ( ) and ( ) demonstrated improved binding as compared to both the natural ligand sLex and a previously reported inhibitor TBC-265 ( , R = 3-CH2CO2H).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787959
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