• Title of article

    Synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes

  • Author/Authors

    Dae-Kee Kim، نويسنده , , Jongsik Gam، نويسنده , , Yong-Baik Cho، نويسنده , , Hun-Taek Kim، نويسنده , , Key H. Kim، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1996
  • Pages
    6
  • From page
    647
  • To page
    652
  • Abstract
    The synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes 10–15 are described. cis-Dichloro[(2R,3R)-2,3-dimethoxy-1,4-diaminobutane]platinum(II) (bd11) and cis-(cyclobutane01,1-dicarboxylato)[(2R,3R)-2,3-dihydroxy-1,4-diaminobutane]platinum(II) (bd13) showed the potent antitumor activity against L1210 leukemia in mice with % T/C values of around 200.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1996
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    787974