Title of article
A Hammett correlation for CC-1065 and duocarmycin analogs: Magnitude of substituent electronic effects on functional reactivity
Author/Authors
Dale L. Boger، نويسنده , , Jeffrey A. McKie، نويسنده , , Nianhe Han، نويسنده , , Christine M. Tarby، نويسنده , , Haiqiong W. Riggs، نويسنده , , Paul A. Kitos، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
659
To page
664
Abstract
A quantitative Hammett study of the magnitude of the electronic effects of a C7 substituent on the functional reactivity of N-BOC-CBI (5, R=H), its impact on biological properties, details of the mechanism of the acid-catalyzed nucleophilic addition to the activated cyclopropane, and its implications on the origin of the DNA alkylation selectivity of this class of agents is detailed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787976
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