Title of article
Synthesis of polyamide nucleic acids (PNAs) using a novel Fmoc/Mmt protecting-group combination
Author/Authors
G. Breipohl، نويسنده , , J. Knolle، نويسنده , , D. Langner، نويسنده , , G. OʹMalley، نويسنده , , E. Uhlmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
665
To page
670
Abstract
The preparation of 9-Fluorenylmethoxycarbonyl(Fmoc) protected building blocks for the synthesis of polyamide nucleic acids (PNAs) is described. Use of 4-Methoxyphenyldiphenylmethyl (Mmt)-protecting groups for the exocyclic amino function of the nucleobases enhances the solubility of the monomers and allows final deprotection by mild acid treatment. The novel synthetic route is exemplified by the synthesis of heptameric and octameric PNAs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787977
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