Title of article
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. The synthesis and biological activity of a series of malonester amides
Author/Authors
D. R. Sliskovic، نويسنده , , J. A. Picard، نويسنده , , W. H. Roark، نويسنده , , A. D. Essenburg، نويسنده , , B. R. Krause، نويسنده , , L. L. Minton، نويسنده , , J. F. Reindel، نويسنده , , R. L. Stanfield، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
713
To page
718
Abstract
The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s, was shown to be a potent inhibitor of both the intestinal and arterial enzymes, bioactive upon oral dosing (ex vivo bioassay) and efficacious in a clinically relevant rodent model of preestablished hypercholesterolemia.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787986
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